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bioRxiv · 10.1101/2025.08.05.668726

Coordinate-Dependent Neuroinflammation and Metabolic Disruption Following Experimental Traumatic Brain Injury

Kaza, S.·Natera-Rodriguez, D. E.·Grande, A. W.
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Abstract

Traumatic brain injury (TBI) is a leading cause of long-term neurological dysfunction, with secondary neuroinflammation playing a pivotal role in disease progression. Microglia, the brains resident immune cells, respond to injury in a spectrum of activation states, influencing neuronal survival and cognitive recovery. While past studies have broadly examined neuroinflammatory responses following TBI, the influence of injury approach--specifically, anterior vs. posterior impact--on microglial activation and neuronal damage remains unexplored. This study investigated how the site of controlled cortical impact (CCI) in a moderate TBI model alters neuroinflammatory responses and neuronal vulnerability, providing key insights into coordinate-specific mechanisms of injury.

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Kaza, S., Natera-Rodriguez, D. E., Grande, A. W.. 2025-08-07. Coordinate-Dependent Neuroinflammation and Metabolic Disruption Following Experimental Traumatic Brain Injury. https://doi.org/10.1101/2025.08.05.668726

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