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bioRxiv · 10.1101/2025.07.27.666103

Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult Attention-Deficit/Hyperactivity Disorder

Pinggal, E.·Jackson, J.·Kusztor, A.·Chapman, D.·Windt, J.·Drummond, S.·Silk, T.·Bellgrove, M. A.·Andrillon, T.
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Abstract

BackgroundAttention-Deficit/Hyperactivity Disorder (ADHD) is characterised by behavioural variability and heightened inattention associated with increased mind wandering (MW) and mind blanking (MB). Individuals with ADHD frequently experience sleep disorders and excessive daytime sleepiness, suggesting interactions between attention and arousal systems. Research examining brain activity using electroencephalography (EEG) has demonstrated that sleep-like slow waves (SW) during wakefulness are linked to inattention in neurotypical individuals, particularly following sleep deprivation, yet their role in ADHD remains unclear. This study investigated whether individuals with ADHD present with altered waking SW distribution compared to neurotypical controls and whether SW explain attentional difficulties in ADHD. MethodsAdults with (n = 32) and without ADHD (n = 31) completed a sustained attention task while EEG recorded brain activity. Mental state probes (on-task, MW, MB) were embedded within the task. Sleep-like SW reflect a slowing of cortical activity and was detected from EEG activity. Omission/commission errors, reaction time (RT), RT variability, mental state reports and subjective sleepiness were analysed. Mediation analysis examined whether SW density explained ADHD-related performance differences. ResultsIndividuals with ADHD exhibited more commission errors, MW and MB, and higher SW density (SW/min), particularly over parieto-temporal electrodes. Increased SW density correlated with higher omission errors, slower RTs, greater RT variability, and elevated sleepiness ratings. On-task reports were negatively correlated with SW density. Mediation analysis revealed that SW density significantly accounted for ADHD-related attentional difficulties. ConclusionsWake SW may explain attentional difficulties in ADHD, providing a potential mechanistic link between sleep disturbances and attentional fluctuations.

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Pinggal, E., Jackson, J., Kusztor, A., Chapman, D., Windt, J., Drummond, S., Silk, T., Bellgrove, M. A., Andrillon, T.. 2025-07-31. Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult Attention-Deficit/Hyperactivity Disorder. https://doi.org/10.1101/2025.07.27.666103

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