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bioRxiv · 10.1101/2025.07.22.666077

The CFII components PCF11 and Cbc change subnuclear localization as cells differentiate in the male germ line adult stem cell lineage

Nava, I.·Fuller, M. T.·Gallicchio, L.
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Abstract

Stage specific increased expression of PCF11 and Cbc, the two components of Cleavage Factor complex II, contribute to developmentally regulated 3UTR shortening due to alternate polyadenylation of nascent RNA molecules in Drosophila spermatocytes compared to spermatogonia. Here, we show that both Cbc and PCF11 change subnuclear localization during male germ cell differentiation, from homogeneous in the nucleus in spermatogonia and early spermatocytes to concentrated around the nucleolus in later spermatocyte stages.

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Nava, I., Fuller, M. T., Gallicchio, L.. 2025-07-22. The CFII components PCF11 and Cbc change subnuclear localization as cells differentiate in the male germ line adult stem cell lineage. https://doi.org/10.1101/2025.07.22.666077

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