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bioRxiv · 10.1101/2025.07.17.665441

Understanding Structural Mechanics of Ligated DNA Crystals via Molecular Dynamics Simulation

Abstract

DNA self-assembly is a highly programmable method that can construct arbitrary architectures based on sequence complementarity. Among various constructs, DNA crystals are macroscopic crystalline materials formed by assembling motifs via sticky end association. Due to their high structural integrity and size ranging from tens to hundreds of micrometers, DNA crystals offer unique opportunities to study structural properties and deformation behaviors of DNA assemblies. For example, enzymatic ligation of sticky ends can selectively seal nicks resulting in more robust structures with enhanced mechanical properties. However, the research efforts have been mostly on experiments such as different motif designs, structural optimization, or new synthesis methods, while their mechanics are not fully understood. The complex properties of DNA crystals are difficult to study via experiment alone, and numerical simulation can complement and inform the experiment. Coarse-grained molecular dynamics (MD) simulation is a powerful tool that can probe the mechanics of DNA assemblies. Here, we investigate DNA crystals made of four different motif lengths with various ligation patterns (full ligation, major directions, connectors, and in-plane) using oxDNA, an open-source, coarse-grained MD platform. We find that several distinct deformation stages emerge in response to mechanical loading and that the number and the location of the ligated nucleotides can significantly modulate structural behaviors. These findings should be useful for predicting crystal properties and thus improving the design.

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BibTeXRIS

Kim, Y. H., Madhvacharyula, A. S., Li, R., Swett, A. A., Seo, S., Batchelder-Schwab, E. J., Siraj, N., Mao, C., Choi, J. H.. 2025-07-22. Understanding Structural Mechanics of Ligated DNA Crystals via Molecular Dynamics Simulation. https://doi.org/10.1101/2025.07.17.665441

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