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bioRxiv · 10.1101/2025.07.10.664255

Stabilin levels are related to atherosclerotic plaque burden in type 2 diabetes mellitus individuals

Giannousi, E.·Georgiadou, C.·Kassi, E.·Vlachogiannis, N.·Aggeli, I. K.·Sfikakis, P. P.·Tentolouris, N.·Protogerou, A. D.·Kararigas, G.·Chatzigeorgiou, A.

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Abstract

Type 2 diabetes mellitus (T2DM) is a global burgeoning health problem that increases the risk of atherosclerotic cardiovascular disease (ASCVD). Infiltration and oxidative modification of low-density lipoprotein (LDL) cholesterol in the arterial wall and chronic inflammation comprise central pathogenetic mechanisms in ASCVD. Scavenger receptors, particularly Stabilin-1 (Stab1) and Stabilin-2 (Stab2), are pivotal in the clearance of oxidized LDL (oxLDL) cholesterol and pro-atherogenic ligands from circulation. However, their role in atherosclerosis development in the spectrum of T2DM remains poorly characterized. We assessed circulating levels of Stab1, Stab2, and their ligands (TGFbI, Periostin and Reelin) in a cohort of 33 T2DM and 21 non-diabetic individuals, stratified by their atherosclerotic plaque burden as assessed by high-resolution vascular ultrasound. Associations between stabilins, their ligands and conventional cardiovascular risk factors were evaluated. Stab1 levels were significantly elevated in individuals with higher atherosclerotic plaque burden (p<0.05), while Reelin levels were marginally elevated, both in the total study cohort and among T2DM patients. Stab1 levels positively correlated with body mass index and inversely correlated with total cholesterol, LDL, and high-density lipoprotein (HDL) cholesterol levels. Our findings indicate that Stab1 may serve as a marker of dysregulated lipid metabolism and increased atherosclerotic plaque burden in individuals with T2DM. Larger prospective studies are warranted to establish the prognostic and potentially therapeutic value of Stab1 and to clarify its mechanistic role in diabetic atherosclerosis.

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Giannousi, E., Georgiadou, C., Kassi, E., Vlachogiannis, N., Aggeli, I. K., Sfikakis, P. P., Tentolouris, N., Protogerou, A. D., Kararigas, G., Chatzigeorgiou, A.. 2025-07-16. Stabilin levels are related to atherosclerotic plaque burden in type 2 diabetes mellitus individuals. https://doi.org/10.1101/2025.07.10.664255

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