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bioRxiv · 10.1101/2025.07.10.663870

Beta burst waveform extraction using novel 4He-OPMs

Gutteling, T. P.·Szul, M. J.·Daligault, S.·Labyt, E.·Jung, J.·Bonaiuto, J. J.·Schwartz, D. P.
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Abstract

Studying the electrophysiology of motor preparation and execution is challenging due to the restrictions often placed on the experimental paradigm by the imaging modality. MEG is well suited to track temporal brain dynamics while offering good spatial resolution, but requires an absence of head motion due to the fixed helmet and associated cryogenic cooling system. Here we used novel, room temperature, wearable optically pumped magnetometers using Helium to measure the MEG in a motor preparation and execution task and compare this with classic SQUID-MEG. Beta band activity (13-30Hz) is widely associated with motor activity, and it has become widely accepted that beta activity occurs in bursts rather than sustained activity. Here we used a novel beta burst extraction pipeline to look at not only the occurrence of the beta bursts across the timecourse of motor preparation and execution, but at the specific waveforms of the beta burst that evolve over time. Results show that specific beta burst waveforms show strong task relevant modulations of burst rate. Beta burst waveforms extracted using Helium-OPMs were very similar to those extracted using SQUID-MEG, with comparable modulations of burst rate over time for specific waveforms. This shows a promising step to obtaining high quality electrophysiological data in less restricted paradigms.

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Gutteling, T. P., Szul, M. J., Daligault, S., Labyt, E., Jung, J., Bonaiuto, J. J., Schwartz, D. P.. 2025-07-15. Beta burst waveform extraction using novel 4He-OPMs. https://doi.org/10.1101/2025.07.10.663870

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