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bioRxiv · 10.1101/2025.06.18.660412

Coalescent theory of the {psi} directionality index

Abstract

The{psi} directionality index was introduced by Peter & Slatkin (Evolution 67: 3274-3289, 2013) to infer the direction of range expansions from single-nucleotide polymorphism variation. Computed from the joint site frequency spectrum for two populations,{psi} uses shared genetic variants to measure the difference in the amount of genetic drift experienced by the populations, associating excess drift with greater distance from the origin of the range expansion. Although{psi} has been successfully applied in natural populations, its statistical properties have not been well understood. In this paper, we define {Psi} as a random variable originating from a coalescent process in a two-population demography. For samples consisting of a pair of diploid genomes, one from each of two populations, we derive expressions for moments [E] [{Psi}k] for standard parameterizations of bottlenecks during a founder event. For the expectation [E][{Psi}], we identify parameter combinations that represent distinct demographic scenarios yet yield the same value of [E][{Psi}]. We also show that the variance [V][{Psi}] increases with the time since the bottleneck and bottleneck severity, but does not depend on the size of the ancestral population; the ancestral population size affects{psi} computed from many biallelic loci only through its contribution to the total number of loci available for the computation. Finally, we analyze the values of [E][{Psi}] computed from existing demographic models of Drosophila melanogaster and compare them with empirically computed{psi} . Our work builds the foundation for theoretical treatments of the{psi} index and can help in evaluating its behavior in empirical applications. SummaryThe statistic known as the "directionality index" examines variants shared between two populations with a goal of identifying which population has experienced a greater amount of genetic drift. This study develops theoretical predictions for the directionality index in coalescent models of pairs of populations descended from a common ancestral population. It determines the influence of bottlenecks, population growth, and population sizes on the directionality index. In Drosophila melanogaster, patterns in genomic data accord with the direction of the model predictions, with{psi} suggesting a higher level of drift in European than in African populations.

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BibTeXRIS

Lappo, E., Rosenberg, N. A.. 2025-06-24. Coalescent theory of the {psi} directionality index. https://doi.org/10.1101/2025.06.18.660412

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