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bioRxiv · 10.1101/2025.06.09.658726

Magellon - an extensible platform for cryo-EM data visualization, management, and processing

Khoshbin, B.·Damodar, P.·Garje, R. R.·Schotanus, F. H.·Nair, N.·Wei, L.·Schaefer, J.-H.·Lander, G. C.·Cianfrocco, M. A.·Stagg, S. M.
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Abstract

Single particle cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling high-resolution determination of macromolecular structures. However, the field faces challenges in data management, processing workflow integration, and software extensibility. We present Magellon, an innovative cryo-EM software platform that addresses these challenges through a modern microservices architecture. Magellon consists of an extensible backend with a web-based front end that we call Magellon Viewer. Together, these combine high-performance computing capabilities with an intuitive user interface, enabling researchers to efficiently process and analyze cryo-EM data. The platforms distinguishing features include a plugin-based architecture, distributed processing capabilities, comprehensive monitoring systems, and a novel approach to data organization and visualization. A key philosophy of the approach is that the Magellon backend provides a platform that uses robust industry-standard libraries to orchestrate computational tasks while offering users and developers flexibility in selecting the computational resources for performing calculations. Magellon represents a significant advancement in cryo-EM software infrastructure, offering flexibility, scalability, and extensibility while maintaining ease of use.

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Khoshbin, B., Damodar, P., Garje, R. R., Schotanus, F. H., Nair, N., Wei, L., Schaefer, J.-H., Lander, G. C., Cianfrocco, M. A., Stagg, S. M.. 2025-06-11. Magellon - an extensible platform for cryo-EM data visualization, management, and processing. https://doi.org/10.1101/2025.06.09.658726

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