Differential microstructural development within sensorimotor cortical regions: A diffusion MRI study in preterm and full-term infants

Abstract

The sensorimotor system develops early in utero and supports the emergence of body representations critical for perception, action, and interaction with environment. While somatotopic protomaps are already developed in the primary somatosensory and motor cortices in late pregnancy, little is known about the anatomical substrates of this functional specialization. In this study, we aimed to decipher the microstructural properties of these regions in the developing brain. Using advanced diffusion MRI and post-processing tools, we parcellated the pre- and post-central gyri into microstructurally distinct clusters along the lateral-to-medial axis in full-term neonates, confirming the early differentiation within sensorimotor regions. These clusters were further analyzed in preterm infants scanned near birth and at term-equivalent age (TEA), compared with another group of full-term neonates. Applying a multivariate Mahalanobis distance approach, we quantified deviations in preterm cortical microstructure relative to the full-term reference. Preterm infants showed significant region- and position-specific deviations at both ages, though these were smaller at TEA, consistently with ongoing maturation during the pre-term period. Differences between the pre- and post-central gyri, and along the somatotopic axis, suggested differential vulnerability to prematurity. In particular, the motor regions appeared to be at a more advanced stage of maturation close to birth and less vulnerable at TEA than somatosensory regions. An opposite trend was observed for lateral positions related to mouth representation compared with intermediary and medial positions. These findings support the notion that early sensorimotor cortical specialization is microstructurally emergent during gestation and sensitive to atypical developmental context of preterm birth.