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bioRxiv · 10.1101/2025.05.31.657076

A bio-informatics approach to identify new drug targets in multidrug-resistant bacteria

Ramsden, I.·de Jong-Hoogland, D.·Chiam, A. J.·Ulmschneider, M. B.
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Abstract

Antibiotic resistance poses a global health crisis. In order to develop new antibiotic agents, it is crucial to identify drug targets in multidrug-resistant bacteria. Criteria for such a target are an -helical, essential membrane protein, that is non-homologues with the human membrane proteome, and present across multiple bacterial species. Using a stepwise subtractive genomics approach, the membrane protein F0F1 ATP synthase subunit C was identified as a non-human analogues drug target that is present in 11 bacterial species.

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Ramsden, I., de Jong-Hoogland, D., Chiam, A. J., Ulmschneider, M. B.. 2025-06-03. A bio-informatics approach to identify new drug targets in multidrug-resistant bacteria. https://doi.org/10.1101/2025.05.31.657076

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