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bioRxiv · 10.1101/2025.05.28.656660

Doxycycline Release From Cyclodextrin Oligomer-Containing Collagen Gels

Trout, E.·Palomo, L.·von Recum, H. A.·Eppell, S. J.
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Abstract

Dental implants commonly suffer from chronic peri-implantitis arising from infection and inflammation at the abutment/gingiva interface, primarily because they fail to replicate the collagen-rich soft tissue interface between natural teeth and the jawbone. Current treatment strategies involve frequent administration of systemic antibiotics and collagenase inhibitors which complicates clinical management. A localized controlled drug-release approach may offer a way to simplify this clinical management. In this study, we investigate doxycycline loading and release from a collagen hydrogel containing entrapped oligomers of {gamma}-cyclodextrin (CD). Incorporating these cyclodextrin oligomers increased the releasable amount of doxycycline by 220% and reduced its release rate fivefold. The resulting enhancement in both drug loading and release control expands the potential for further development of a collagen-coated dental implant.

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Trout, E., Palomo, L., von Recum, H. A., Eppell, S. J.. 2025-06-01. Doxycycline Release From Cyclodextrin Oligomer-Containing Collagen Gels. https://doi.org/10.1101/2025.05.28.656660

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