Longitudinal Habituation and Novelty Detection neural responses from infancy to early childhood in The Gambia and UK

Blasi Ribera, A.; Blanco Maniega, B.; McCann, S.; Mbye, E.; Touray, E.; Rozhko, M.; Milosavljevic, B.; Katus, L.; Saidykhand, M.; Ceesay, M.; Fadera, T.; Ghillia, G.; Perapoch Amado, M.; Moore, S. E.; Elwell, C. E.; Lloyd-Fox, S.

doi:10.1101/2025.05.23.655801

bioRxiv · 10.1101/2025.05.23.655801

Longitudinal Habituation and Novelty Detection neural responses from infancy to early childhood in The Gambia and UK

Blasi Ribera, A.·Blanco Maniega, B.·McCann, S.·Mbye, E.·Touray, E.·Rozhko, M.·Milosavljevic, B.·Katus, L.·Saidykhand, M.·Ceesay, M.·Fadera, T.·Ghillia, G.·Perapoch Amado, M.·Moore, S. E.·Elwell, C. E.·Lloyd-Fox, S.

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Abstract

As infants and young children learn from and respond to their environment, their development is driven by their ability to filter out irrelevant stimuli and respond to salient stimuli. While sources and types of stimuli vary across cultural contexts, research to understand the neural mechanisms of these behaviors have largely focused on relatively homogeneous populations in high income settings. To address this lack of diverse representation the Brain Imaging for Global health project (BRIGHT) collected longitudinal data in The Gambia (N=204) and the UK (N=61). Here we present results of the Habituation and Novelty Detection (HaND) fNIRS neuroimaging task. Gambian infants showed persistent response suppression (Habituation) at all visits (from 5mo to 60mo) while Novelty Detection was only observed once infants reached 18 and 24mo. In the UK, infants only showed persistent habituation from 5-12mo, while the response was not evident at 18 and 24mo. Furthermore, in contrast to The Gambia, alongside the habituation patterns observed Uk infants showed novelty detection from 5-12mo. This is the first longitudinal description of the HaND response in individuals from different contextual backgrounds across such a broad age range and number of time points, revealing different patterns of specialization in The Gambia and UK. HighlightsO_LIThis is the first characterization of Habituation and Novelty Detection (HaND) responses in infants and young children from contrasting settings across low and high-income countries. C_LIO_LIIn the Gambian cohort, Habituation was typically observed from 5 to 60months; only weak patterns of Novelty Detection were observed at 18 and 24months. C_LIO_LIIn the UK cohort, HaND responses were observed up to 12months of age; but were not evident at 18 and 24months. C_LIO_LIDevelopmental trajectories of HaND responses follow different patterns of specialization from birth to five years of age in individuals living in different contexts. C_LI

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Blasi Ribera, A., Blanco Maniega, B., McCann, S., Mbye, E., Touray, E., Rozhko, M., Milosavljevic, B., Katus, L., Saidykhand, M., Ceesay, M., Fadera, T., Ghillia, G., Perapoch Amado, M., Moore, S. E., Elwell, C. E., Lloyd-Fox, S.. 2025-05-28. Longitudinal Habituation and Novelty Detection neural responses from infancy to early childhood in The Gambia and UK. https://doi.org/10.1101/2025.05.23.655801

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