Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults

Fischer, L.; Adams, J. N.; Molloy, E. N.; Tremblay-Mercier, J.; Remz, J.; Pichet Binette, A.; Rajah, M. N.; Villeneuve, S.; Maass, A.; PREVENT-AD Research Group,

doi:10.1101/2025.05.16.654628

bioRxiv · 10.1101/2025.05.16.654628

Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults

Fischer, L.·Adams, J. N.·Molloy, E. N.·Tremblay-Mercier, J.·Remz, J.·Pichet Binette, A.·Rajah, M. N.·Villeneuve, S.·Maass, A.·PREVENT-AD Research Group,

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Abstract

Changes in functional connectivity (FC) strength involving the medial temporal lobe (MTL) and posteromedial cortex (PMC) are related to early Alzheimers pathology and alterations in episodic memory performance in cognitively unimpaired older adults, but their dynamics remain unclear. We examined how longitudinal changes in FC involving MTL and PMC during resting-state, episodic memory encoding, and retrieval relate to subsequent amyloid- and tau- PET burden, longitudinal episodic memory performance, and the APOE4 genotype in 152 cognitively unimpaired older adults from the PREVENT-AD cohort. We found APOE4- and fMRI paradigm-dependent associations of change in FC strength with pathology burden and change in episodic memory performance. Decreasing FC over time, or "hypoconnectivity", within PMC during rest in APOE4 carriers and during retrieval in APOE4 non-carriers was related to more amyloid and tau, respectively. Conversely, increasing FC over time, or "hyperconnectivity", within MTL during encoding in APOE4 carriers and between MTL and PMC during retrieval independent of APOE4 status was related to more tau. Further, increasing FC between MTL and PMC during rest, unlike during encoding, was beneficial for episodic memory. Our study highlights that pathology-related episodic memory network changes manifest differently during rest and task and have differential implications for episodic memory trajectories.

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Fischer, L., Adams, J. N., Molloy, E. N., Tremblay-Mercier, J., Remz, J., Pichet Binette, A., Rajah, M. N., Villeneuve, S., Maass, A., PREVENT-AD Research Group,. 2025-05-21. Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults. https://doi.org/10.1101/2025.05.16.654628

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