CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION

roullet, p.; Koehl, M.; Delage, P.; Guillemot, F.; Abrous, N.

doi:10.1101/2025.05.15.654267

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bioRxiv · 10.1101/2025.05.15.654267

CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION

roullet, p.·Koehl, M.·Delage, P.·Guillemot, F.·Abrous, N.

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Abstract

The dentate gyrus contains neurons generated during development and adulthood, yet their distinct roles remain unclear. Using a transgenic mouse model, we show that adult-born neurons contribute to pattern completion, essential for episodic memory. This has implications for aging, PTSD, and addiction, where excessive pattern completion leads to maladaptive memories. Targeting ABNs could offer new therapeutic strategies to regulate memory processes and improve mental health.

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roullet, p., Koehl, M., Delage, P., Guillemot, F., Abrous, N.. 2025-05-20. CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION. https://doi.org/10.1101/2025.05.15.654267

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