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bioRxiv · 10.1101/2025.04.11.648349

In vitro Activity of Citrus IntegroPectin against Breast Cancer and Colon Cancer

D'Anna, C.·Di Sano, C.·Li Petri, G.·Angellotti, G.·Ciriminna, R.·Pagliaro, M.
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Abstract

In vitro investigations of citrus IntegroPectin bioconjugates obtained through acoustic cavitation in water of different citrus fruit (lemon, red orange, and sweet orange) processing waste revealed the conjugates ability to inhibit the migratory features of Caco-2 colon cancer and MCF-7 breast cancer cells. All tested pectins substantially reduced cell migration of both tumor cell lines already at 0.5 and 1.0 mg/mL concentration. Dissolved in aqueous phase, furthermore, red orange and lemon IntegroPectin phytocomplexes at 5 and 10 mg/mL load reduced cell viability for both cell lines. Adding to promising results against lung cancer, these outcomes support further investigation of IntegroPectin citrus pectins for the treatment of cancer.

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D'Anna, C., Di Sano, C., Li Petri, G., Angellotti, G., Ciriminna, R., Pagliaro, M.. 2025-04-11. In vitro Activity of Citrus IntegroPectin against Breast Cancer and Colon Cancer. https://doi.org/10.1101/2025.04.11.648349

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