Search bioRxiv⌕ Search

bioRxiv · 10.1101/2025.03.17.643669

Comparing a computational model of visual problem solving with human vision on a difficult vision task.

Abstract

Human vision is not merely a passive process of interpreting sensory input but can also function as a problem-solving process incorporating generative mechanisms to interpret ambiguous or noisy data. This synergy between the generative and discriminative components, often described as analysis-by-synthesis, enables robust perception and rapid adaptation to out-of-distribution inputs. In this work, we investigate a computational implementation of the analysis-by-synthesis paradigm using genetic search in a generative model, applied to a visual problem-solving task inspired by star constellations. The search is guided by low-level cues based on the structural fitness of candidate solutions compared to the test images. This dataset serves as a testbed for exploring how inferred signals can guide the synthesis of suitable solutions in ambiguous conditions, framing visual inference as an instance of complex problem solving. Drawing on insights from human experiments, we develop a generative search algorithm and compare its performance to humans, examining factors such as accuracy, reaction time, and overlap in drawings. Our results shed light on possible mechanisms of human visual problem solving and highlight the potential of generative search models to emulate aspects of this process. Author summaryHuman vision is not just about passively receiving information from the environment. Rather, it also involves actively making sense of what we see. When faced with unclear or incomplete visual input, our brains use prior knowledge to fill in gaps and create the most likely interpretation. This ability helps us recognize objects and patterns even in difficult conditions. In this study, we explore how this process can be replicated using computer models. Specifically, we test a method that generates possible interpretations of ambiguous visual data, inspired by the way people recognize star constellations. By comparing the models performance with human participants, we examine how well it mirrors human perception. We analyze factors such as accuracy, response time, and similarities in the interpretations produced. Our findings offer insights into how people make sense of uncertain visual information and suggest ways in which computer models can be designed to mimic this ability. These results can contribute to our understanding of human perception as well as help advance artificial vision systems beyond simple pattern recognition.

Source connections

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Khajuria, T., Tulver, K., Aru, J.. 2025-03-17. Comparing a computational model of visual problem solving with human vision on a difficult vision task.. https://doi.org/10.1101/2025.03.17.643669

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related preprints

The Unreasonable Effectiveness of Cell Types in Describing Neuronal Physiological Features

Single-cell RNA sequencing (scRNA-seq) captures detailed gene expression profiles at scale, while patch-clamp recordings measure intrinsic neuronal electrophysiological properties. Modeling the relations between these two modalities remains a challenge. Here, we compare how well electrophysiological features can be predicted by traditional transcriptomic cell type classification, representations derived from a foundational model (scGPT) pretrained on large-scale scRNA-seq datasets, ion channel-coding genes, and highly variable genes. Using paired transcriptomic and electrophysiological patch-sequencing data from 495 human neurons from neurosurgical tissue, we find that cluster-level cell type representations consistently outperform highly variable gene selection, ion channel gene selection, and context-enriched scGPT embeddings. Notably, performance varies across model architectures and initializations, and the best results are obtained by combining the outputs of separate cell type and scGPT-based models. Together, these findings suggest that traditional discrete cellular classification is highly effective in predicting physiological features. For maximum performance it can be complemented by pretrained transformer models.

neuroscience↗

A nonlinear inhibition pathway underlying cortical responses to tuned holographic optogenetic perturbations

Optogenetics enables causal manipulation of cortical activity. Perturbation responses can be counterintuitive due to network interactions, making theory essential for predicting them. Existing approaches often rely on linear approximations, which fail for many biologically relevant perturbations. Here we develop a nonlinear theory of responses to holographic perturbations in cell-type-specific recurrent networks with structured connectivity. We fit a nonlinear model to mouse V1 data, which shows cotuned-ensemble suppression: perturbing spatially clustered neurons with similar preferred orientations yields markedly stronger short-range suppression than perturbing untuned ensembles. We show that cotuned-ensemble suppression arises from a feature-tuned, nonlinear inhibition pathway implicating somatostatin-positive (SST) interneurons. The theory predicts that cotuned ensembles suppress parvalbumin-positive (PV) neurons but facilitate SST neurons, and links the degree of cotuned-ensemble suppression or facilitation to the variance of the SST response. This framework identifies mechanisms by which nonlinear inhibition sculpts cortical dynamics and establishes a predictive basis for targeted optogenetic interventions.

neuroscience↗

Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimers disease

The apolipoprotein E {varepsilon}4 (APOE {varepsilon}4) allele is the strongest genetic risk factor for late-onset Alzheimers disease (AD). However, the underlying molecular mechanisms remain unclear. This study included 1691 participants from the Religious Orders Study and Rush Memory and Aging Project (ROSMAP), 1226 participants from the Accelerating Medicines Partnership - Alzheimers Disease (AMP-AD) Diverse Cohorts Study, and 735 participants from the Alzheimers Disease Neuroimaging Initiative (ADNI). To characterise APOE {varepsilon}4 molecular effects, we analysed proteomic data from plasma, cerebrospinal fluid (CSF), and induced pluripotent stem cell (iPSC)-derived astrocytes and neurons, as well as transcriptomic and proteomic data from multiple brain regions. The association of APOE {varepsilon}4 with AD neuropathology was also examined. APOE {varepsilon}4 carriers shared a plasma proteomic signature enriched for immune processes, irrespective of AD diagnosis. A machine learning classifier trained on this signature discriminated APOE {varepsilon}4 carriers from non-carriers in an independent cohort using CSF proteomics. APOE {varepsilon}4 carriage was associated with higher Braak stages and Consortium to Establish a Registry for Alzheimers Disease (CERAD) score. However, only limited APOE {varepsilon}4-associated transcriptomic and proteomic changes were observed in bulk brain tissue, with poor cross-layer concordance. Proteomic analyses of iPSC-derived astrocytes and neurons further revealed cell-type-specific APOE {varepsilon}4-associated changes. APOE {varepsilon}4 is associated with a consistent proteomic signature across plasma and CSF. Its molecular effects in the brain differ across cell types, brain regions and molecular layers. These findings support the need for cell-type-resolved multi-omic studies to elucidate how APOE {varepsilon}4 confers AD risk.

neuroscience↗