HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions

Rokicki, K.; Schauder, D.; Olbris, D. J.; Goina, C.; Clements, J.; Edson, P.; Kawase, T.; Svirskas, R.; Arshadi, C.; Feng, D.; Chandrashekar, J.; Ferreira, T. A.; MouseLight Project Team,

doi:10.1101/2025.03.13.642887

bioRxiv · 10.1101/2025.03.13.642887

HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions

Rokicki, K.·Schauder, D.·Olbris, D. J.·Goina, C.·Clements, J.·Edson, P.·Kawase, T.·Svirskas, R.·Arshadi, C.·Feng, D.·Chandrashekar, J.·Ferreira, T. A.·MouseLight Project Team,

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Abstract

HortaCloud is a cloud-based, open-source platform designed to facilitate the collaborative reconstruction of long-range projection neurons from whole-brain light microscopy data. By providing virtual environments directly within the cloud, it eliminates the need for costly and time-consuming data downloads, allowing researchers to work efficiently with terabyte-scale volumetric datasets. Standardization of computational resources in the cloud make deployment easier and more predictable. The pay-as-you-go cloud model reduces adoption barriers by eliminating upfront investments in expensive hardware. Finally, HortaClouds decentralized architecture enables global collaboration between researchers and between institutions.

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Rokicki, K., Schauder, D., Olbris, D. J., Goina, C., Clements, J., Edson, P., Kawase, T., Svirskas, R., Arshadi, C., Feng, D., Chandrashekar, J., Ferreira, T. A., MouseLight Project Team,. 2025-03-14. HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions. https://doi.org/10.1101/2025.03.13.642887

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