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bioRxiv · 10.1101/2025.03.12.642845

AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt

Lang, B.·Babu, M. M.
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Abstract

Synchronizing protein structure predictions with sequence databases is crucial for their accuracy. We developed AlphaSync (alphasync.stjude.org), a pipeline and database that provides updated AlphaFold structure models for currently 39,961 UniProt proteins, including isoforms. Moreover, AlphaSync enhances 2.6 million structures with residue-level features, including solvent accessibility, dihedral angles, intrinsic disorder predictions, and 4.7 billion atom-level noncovalent contacts. AlphaSyncs user-friendly interface enables structural analyses at scale across up-to-date proteomes for 42 species.

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Lang, B., Babu, M. M.. 2025-03-14. AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt. https://doi.org/10.1101/2025.03.12.642845

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