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bioRxiv · 10.1101/2025.02.24.639975

Bioinformatics Study of Genetic Variability in Obelisks

Hernandez-Walias, F. J.·Reinosa, R.
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Abstract

MotivationThe importance of in silico genetic variability analyses of new biological entities, such as obelisks, lies in their potential to serve as a starting point for experimental studies. The study of obelisks could open new horizons in the field of biological sciences. ResultsSeveral findings have been determined, including high conservation among the sequences within each cluster, despite the presence of significant nucleotide mutations; high variability among the Oblin-1 proteins found in the consensus sequences of each cluster, despite all sharing a known conserved region; structural consistency in the 3D model of the Oblin-2 consensus with previous studies; a series of nucleotide and protein- level consensus sequences for each cluster, where nucleotide-level patterns show color- coded conservation percentages that could be used in further research, such as primer or probe design, and protein-level sequences are presented in FASTA format for Oblin- 1, Oblin-2, and unknown Open Reading Frames (ORFs).

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Hernandez-Walias, F. J., Reinosa, R.. 2025-02-28. Bioinformatics Study of Genetic Variability in Obelisks. https://doi.org/10.1101/2025.02.24.639975

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