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bioRxiv · 10.1101/2025.02.13.638101

Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture

Kohlhas, V.·Jestrabek, H.·Rebollido-Rios, R.·Truong, T. T.·Zoelzer, R.·Schreurs, L. D.·von Lom, A.·vom Stein, A. F.·Hallek, M.·Nguyen, P.-H.
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Abstract

In this brief report, we evaluated various macrophage coculture systems for their CLL-feeding potential, phagocytosis capacity, induction of treatment resistance in CLL cells, and their impact on the transcriptional profiles of CLL cells.

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Kohlhas, V., Jestrabek, H., Rebollido-Rios, R., Truong, T. T., Zoelzer, R., Schreurs, L. D., von Lom, A., vom Stein, A. F., Hallek, M., Nguyen, P.-H.. 2025-02-17. Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture. https://doi.org/10.1101/2025.02.13.638101

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