Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex

Khan, A. U.; Hoy, C. W.; Anderson, K. L.; Piai, V.; King-Stephens, D.; Laxer, K. D.; Weber, P.; Lin, J. J.; Knight, R. T.; Bentley, J. N.

doi:10.1101/2025.02.12.637987

bioRxiv · 10.1101/2025.02.12.637987

Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex

Khan, A. U.·Hoy, C. W.·Anderson, K. L.·Piai, V.·King-Stephens, D.·Laxer, K. D.·Weber, P.·Lin, J. J.·Knight, R. T.·Bentley, J. N.

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Abstract

Goal-directed behavior requires adjusting cognitive control to both react to and prepare for conflict. Previous work indicates theta oscillations and population activity in dorsomedial prefrontal cortex (dmPFC) and dorsolateral prefrontal cortex (dlPFC) are critical for reactive control. However, the neural mechanisms supporting proactive control are less clear. Here, we investigated the neural basis of behavioral adaptations when control is prepared in anticipation of conflict using intracranial EEG (iEEG) in dmPFC and dlPFC during a Stroop task where conflict frequency was manipulated across blocks. We observed canonical conflict-driven increases in dmPFC theta and in dmPFC and dlPFC local population activity, as indexed by high frequency activity (HFA). Conflict also suppressed theta power in both regions after the response, accentuated a pre-response beta desynchronization selectively in dlPFC, and increased a post-response beta rebound in both regions. Importantly, we identified a pre-trial marker of proactive control where dmPFC theta power increased before trials when conflict was expected, and theta, beta, and HFA conflict signals in both regions were enhanced when conflict was rare and diminished when conflict was common. These findings reveal shared HFA but dissociable oscillatory dynamics in dmPFC and dlPFC during reactive conflict processing, highlight pre-trial dmPFC theta as a potential substrate for proactive control, and refine the roles of dmPFC and dlPFC in control adaptations.

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Khan, A. U., Hoy, C. W., Anderson, K. L., Piai, V., King-Stephens, D., Laxer, K. D., Weber, P., Lin, J. J., Knight, R. T., Bentley, J. N.. 2025-02-13. Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex. https://doi.org/10.1101/2025.02.12.637987

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