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bioRxiv · 10.1101/2025.02.04.635298

A wireless, 60-channel, AI-enabled neurostimulation platform

Rizzuto, D. S.·Hu, Z.·Utin, D.·Kahn, J.·Ho, C.·Smiles, A.·Gross, R. E.·Lega, B. C.·Das, S. R.·Kahana, M. J.
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Abstract

ObjectiveClosed-loop neuromodulatory therapies require devices that can both decode ongoing brain states and deliver multi-site stimulation. MethodsWe describe the Smart Neurostimulation System (SNS), a cranially mounted implant with 60 configurable recording/stimulation channels, inductive power, and onboard spectral-feature classification. In three freely-moving sheep we streamed local-field potentials and conducted two parameter sweep experiments. ResultsCross-validated movement classifiers achieved an average AUC > 0.95. Increasing stimulation amplitude and frequency produced post-stimulation elevations in -band (8-12 Hz) and{gamma} -band (78-82 Hz) power at most target locations. ConclusionThe SNS unifies high-density sensing, real-time brain state decoding, and programmable closed-loop stimulation in a single device, demonstrating behavioral-state prediction and parameter-dependent neuromodulation in vivo. SignificanceThese findings establish a preclinical foundation for biomarker-guided stimulation targeting distributed cortical networks underlying memory and cognition. HighlightsO_LIWireless 60-channel implant enables simultaneous sensing and stimulation C_LIO_LIvine study demonstrates reliable classification of movement and stimulation-related modulation of spectral activity C_LIO_LIThe SNS represents a platform for biomarker-guided neuromodulation therapies C_LI

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Rizzuto, D. S., Hu, Z., Utin, D., Kahn, J., Ho, C., Smiles, A., Gross, R. E., Lega, B. C., Das, S. R., Kahana, M. J.. 2025-02-06. A wireless, 60-channel, AI-enabled neurostimulation platform. https://doi.org/10.1101/2025.02.04.635298

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