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bioRxiv · 10.1101/2025.02.03.636362

Immune-induced TCR-like antibodies regulate specific T cell response

Kishida, K.·Kawakami, K.·Tanabe, H.·Nakai, W.·Yonekura, K.·Yokoyama, S.·Arase, H.
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Abstract

Antigen-specific regulation of T cell response is crucial for limiting hyperimmune response. In this study, we discovered that antibodies specific to the antigen peptide-MHC class II complex are produced during helper T cell responses to various antigens. These antibodies specifically inhibited T cell receptor (TCR) recognition of MHC class II molecules presenting specific antigen peptide. We have termed these antibodies immuneinduced TCR-like antibodies (iTabs). Immunization with peptides containing flanking residues induced iTabs, whereas immunization with peptides lacking flanking residues did not. Furthermore, immunization of iTab-inducible peptide as well as iTab treatment suppressed autoimmune disease development. Our findings provide a strategy for suppressing antigen-specific helper T cell responses using specific peptides, potentially controlling autoimmune diseases.

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Kishida, K., Kawakami, K., Tanabe, H., Nakai, W., Yonekura, K., Yokoyama, S., Arase, H.. 2025-02-08. Immune-induced TCR-like antibodies regulate specific T cell response. https://doi.org/10.1101/2025.02.03.636362

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