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bioRxiv · 10.1101/2025.01.29.635527

Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model

Farras, P.·Murphy, N.·Tipping, W. J.·Ding, Y.·Dwyer, R. M.·Faulds, K.·Pandit, A.·Graham, D.·Spaink, H. P.
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Abstract

Metallacarboranes have long been the subject of attention in the context of medicinal chemistry because of their promising characteristics and unconventional interactions with biological entities. The metal centre has been shown to have a significant influence on the internalisation and cytotoxicity of compounds in human cell lines. Additionally, specific nanomolar concentrations of metallacarboranes have demonstrated toxic effects on MDA-MB-231 cells under in vitro and in vivo conditions. GRAPHICAL ABSTRACT O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=110 SRC="FIGDIR/small/635527v1_ufig1.gif" ALT="Figure 1"> View larger version (67K): org.highwire.dtl.DTLVardef@116eb95org.highwire.dtl.DTLVardef@1c4a181org.highwire.dtl.DTLVardef@474c3forg.highwire.dtl.DTLVardef@dec88c_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Farras, P., Murphy, N., Tipping, W. J., Ding, Y., Dwyer, R. M., Faulds, K., Pandit, A., Graham, D., Spaink, H. P.. 2025-01-29. Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model. https://doi.org/10.1101/2025.01.29.635527

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