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bioRxiv · 10.1101/2025.01.19.633537

A method for inducing a senescence trend in mesenchymal stem cells using D-galactose

Ji, X.·Zhou, X.·Chen, T.·Duan, C.·Tian, W.·Zhu, L.·Ma, Y.·Gao, L.
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Abstract

The aging of the body is accompanied by a decline in tissue function, and this decline mainly stems from the aging of tissue stem cells. Therefore, they play a crucial role in the aging of the body.This study explores the biological characteristics of senescent hUCMSCs by establishing a replicative senescence model of hUCMSCs and a rapid senescence model induced by D - galactose (D-Gal), and analyzing the proliferative capacity, cell viability, cell cycle, pluripotency, and reactive oxygen species (ROS) levels of senescent hUCMSCs.

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Ji, X., Zhou, X., Chen, T., Duan, C., Tian, W., Zhu, L., Ma, Y., Gao, L.. 2025-01-22. A method for inducing a senescence trend in mesenchymal stem cells using D-galactose. https://doi.org/10.1101/2025.01.19.633537

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