Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo

Karle, C.; Filosa, D. I.; Akbarpour, M.; Schuhmacher, N.; Brons, S.; Cee, R.; Schoemers, C.; Scheloske, S.; Petersson, K.; Haberer, T.; Abdollahi, A.; Debus, J.; Tessonnier, T.; Moustafa, M.; Mairani, A.; Dokic, I.

doi:10.1101/2024.12.23.630077

bioRxiv · 10.1101/2024.12.23.630077

Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo

Karle, C.·Filosa, D. I.·Akbarpour, M.·Schuhmacher, N.·Brons, S.·Cee, R.·Schoemers, C.·Scheloske, S.·Petersson, K.·Haberer, T.·Abdollahi, A.·Debus, J.·Tessonnier, T.·Moustafa, M.·Mairani, A.·Dokic, I.

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Abstract

This study showcases the feasibility of oxygen ion ultra-high dose rate irradiation for in vitro and in vivo experiments at the Heidelberg Ion-Beam Therapy Center. The results indicate comparable effectiveness to standard dose rate in pancreatic cancer cell killing and tumor control, highlighting its potential to address challenges in treating radio-resistant tumors.

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Karle, C., Filosa, D. I., Akbarpour, M., Schuhmacher, N., Brons, S., Cee, R., Schoemers, C., Scheloske, S., Petersson, K., Haberer, T., Abdollahi, A., Debus, J., Tessonnier, T., Moustafa, M., Mairani, A., Dokic, I.. 2024-12-23. Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo. https://doi.org/10.1101/2024.12.23.630077

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