Experimental monkeypox virus infection in rats

Rockx, B.; van Keulen, L. J.; Van der Poel, W. H. M.; Arien, K. K.; Vercauteren, K.; van de Water, S.; Harders-Westerveen, J.; Wichgers Schreur, P.; van der Giessen, J.; Maas, M.; Stockhofe, N.; Liesenborghs, L.

doi:10.1101/2024.12.04.626788

bioRxiv · 10.1101/2024.12.04.626788

Experimental monkeypox virus infection in rats

Rockx, B.·van Keulen, L. J.·Van der Poel, W. H. M.·Arien, K. K.·Vercauteren, K.·van de Water, S.·Harders-Westerveen, J.·Wichgers Schreur, P.·van der Giessen, J.·Maas, M.·Stockhofe, N.·Liesenborghs, L.

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Abstract

The global spread of Monkeypox virus (MPXV) clade IIb in 2022/2023 raised concerns about spillback into new animal reservoirs. Experimental inoculation of rats with MPXV resulted in skin lesions and viral shedding in the respiratory tract and skin. These findings suggest a potential role for rats in MPXV transmission.

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Rockx, B., van Keulen, L. J., Van der Poel, W. H. M., Arien, K. K., Vercauteren, K., van de Water, S., Harders-Westerveen, J., Wichgers Schreur, P., van der Giessen, J., Maas, M., Stockhofe, N., Liesenborghs, L.. 2024-12-04. Experimental monkeypox virus infection in rats. https://doi.org/10.1101/2024.12.04.626788

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