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bioRxiv · 10.1101/2024.12.03.626677

The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin

Abdalbari, F. H.·Forgie, B. N.·Zorychta, E. H.·Goyeneche, A. A.·Noman, A. S. M.·Telleria, C. M.
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Abstract

Although there are numerous studies on drug development for ovarian cancer (OC), survival rates for this disease remain low due to platinum (Pt) resistance. Following several rounds of Pt- based chemotherapy, OC cells develop resistance by increasing DNA repair and antioxidant systems. This study aimed to design a treatment approach to combat recurrent stages of OC by repurposing the anti-rheumatic gold complex auranofin (AF). Here we demonstrate that AF enhances the efficacy of cisplatin (CDDP) in Pt-resistant epithelial OC (EOC) cells. The drug combination induces mitochondrial-dependent apoptosis, PARP cleavage, DNA damage, and ROS overproduction. These results suggest the high potential for combining AF with CDDP as a second-line therapy for recurrent EOCs.

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Abdalbari, F. H., Forgie, B. N., Zorychta, E. H., Goyeneche, A. A., Noman, A. S. M., Telleria, C. M.. 2024-12-07. The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin. https://doi.org/10.1101/2024.12.03.626677

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