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bioRxiv · 10.1101/2024.12.01.626240

Striatal Astrocytes Influence Dopamine Dynamics and Behavioral State Transitions

Lazaridis, I.·Ahn, G. A.·Hirokane, K.·Choi, W.·Graybiel, A. M.
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Abstract

We demonstrate here that astrocytes in the striatum interact with striatal dopamine in bidirectional signaling with dopamine release actively driving surges in astrocytic Ca++, which in turn modulate and reduce subsequent dopamine release. These Ca++ surges accurately predict behavioral state changes from task-engaged to task-disengaged states, but fail to predict detailed action parameters. We propose that interactions between striatal astrocytes and dopamine are strong candidates to modulate nigro-striato-nigral loop function underlying on-going behavioral state dynamics.

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Lazaridis, I., Ahn, G. A., Hirokane, K., Choi, W., Graybiel, A. M.. 2024-12-02. Striatal Astrocytes Influence Dopamine Dynamics and Behavioral State Transitions. https://doi.org/10.1101/2024.12.01.626240

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