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bioRxiv · 10.1101/2024.11.25.625229

Enhanced immunogenicity of a Clostridioides difficile TcdB vaccine adjuvanted with a synthetic dual-TLR ligand adjuvant.

Naz, F.·Hagspiel, N.·Xu, F.·Thompson, B.·Moreau, G. B.·Young, M.·Herbein, J.·Fox, C. B.·Petri, W. A.·Abhyankar, M. M.
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Abstract

We report a comprehensive evaluation of the toxin B (TcdB) vaccine adjuvanted with a dual Toll-like receptor ligand liposome adjuvant for Clostridioides difficile infection (CDI). The vaccine completely protected mice from a lethal infection. Compared to alum adjuvanted TcdB, it generated functionally superior systemic antibodies and supported strong memory B cell and gut IgA responses. This pharmaceutically acceptable adjuvant platform holds promise for developing a next-generation CDI vaccine.

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Naz, F., Hagspiel, N., Xu, F., Thompson, B., Moreau, G. B., Young, M., Herbein, J., Fox, C. B., Petri, W. A., Abhyankar, M. M.. 2024-11-26. Enhanced immunogenicity of a Clostridioides difficile TcdB vaccine adjuvanted with a synthetic dual-TLR ligand adjuvant.. https://doi.org/10.1101/2024.11.25.625229

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