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bioRxiv · 10.1101/2024.11.22.624851

Cumulative dose responses for adapting biological systems

Gupta, A.·Sontag, E. D.
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Abstract

This paper introduces the notion of cumulative dose response (cDR). The cDR is the area under the plot of a response variable, an integral taken over a fixed time interval and seen as a function of an input parameter. This work was motivated by the accumulation of cytokines resulting from T cell stimulation, where a non-monotonic cDR has been observed experimentally. However, the notion is of general applicability. A surprising conclusion is that incoherent feedforward loops studied in the systems biology literature, though capable of non-monotonic dose responses, can be mathematically shown to always result in monotonic cDR.

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Gupta, A., Sontag, E. D.. 2024-11-25. Cumulative dose responses for adapting biological systems. https://doi.org/10.1101/2024.11.22.624851

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