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bioRxiv · 10.1101/2024.11.19.624181

Design and synthesis of triazine-based hydrogel for combined targeted doxorubicin delivery and PI3Kinhibition

Mandal, S.·Bhoumick, A.·Singh, A.·Konar, S.·Banerjee, A.·Ghosh, A.·Sen, P.
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Abstract

Melanoma, an aggressive skin cancer originating from melanocytes, presents substantial challenges due to its high metastatic potential and resistance to conventional therapies. Hydrogels, three-dimensional networks of hydrophilic polymers with high water-retention capacities, offer significant promise for controlled drug delivery applications. In this study, we report the synthesis and characterization of hydrogelators based on the triazine molecular scaffold, which self-assemble into fibrous networks conducive to hydrogel formation. Rheological analysis confirmed their hydrogelation properties, while microscopic techniques including FE-SEM and FEG-TEM provided insights into their morphological networks. The drug delivery capability of these hydrogelators was evaluated using doxorubicin, a widely employed anticancer agent, demonstrating enhanced biocompatibility and reduced side effects compared to free doxorubicin. Additionally, the hydrogelators exhibited inhibitory activity against phosphoinositide 3-kinase (PI3K), a key enzyme frequently mutated in cancer, and also involved in melanoma progression. The dual functionality of this delivery system - controlled drug release and PI3K inhibition - highlights the potential of triazine-based hydrogelators as innovative therapeutic platforms for melanoma treatment.

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Mandal, S., Bhoumick, A., Singh, A., Konar, S., Banerjee, A., Ghosh, A., Sen, P.. 2024-11-21. Design and synthesis of triazine-based hydrogel for combined targeted doxorubicin delivery and PI3Kinhibition. https://doi.org/10.1101/2024.11.19.624181

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