Multisensory integration in Peripersonal Space indexes consciousness states in sleep and disorders of consciousness

Bertoni, T.; Ricci, G.; Johr, J.; Donno, B.; Cataldi, J.; Fellrath, J.; Stephan, A.; Foglia, C.; Lecci, S.; Dauvin, F.; Lopez Da Silva, M.; Galigani, M.; Pozeg, P.; Dunet, V.; De Lucia, M.; Noel, J. P.; Magosso, E.; Diserens, K.; Siclari, F.; Serino, A.

doi:10.1101/2024.10.25.619776

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bioRxiv · 10.1101/2024.10.25.619776

Multisensory integration in Peripersonal Space indexes consciousness states in sleep and disorders of consciousness

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Abstract

Conscious experience encompasses not only the awareness of external objects, but also a phenomenal representation of the embodied subject of the experience. The latter is mediated by the integration of multisensory stimuli between the body and the environment, a process mediated by the Peripersonal Space (PPS) system. Here we thus tested the hypothesis that a neural marker of PPS representation may index the presence of conscious experience. Using high-density EEG in awake participants, we identified a "PPS index", characterized by high-beta oscillations in centroparietal regions during the integration of audiotactile stimuli presented near versus far from the body. We then examined this marker across two models of altered consciousness, i.e., sleep and disorders of consciousness. The PPS index persisted during dreaming and waking conscious states but was absent during dreamless, unconscious states. Moreover, the same index predicted behavioural measures of consciousness and clinical outcome in patients recovering from disorders of consciousness. These results suggest that multisensory integration within the PPS is tightly linked to the presence of conscious experience.

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Bertoni, T., Ricci, G., Johr, J., Donno, B., Cataldi, J., Fellrath, J., Stephan, A., Foglia, C., Lecci, S., Dauvin, F., Lopez Da Silva, M., Galigani, M., Pozeg, P., Dunet, V., De Lucia, M., Noel, J. P., Magosso, E., Diserens, K., Siclari, F., Serino, A.. 2024-10-26. Multisensory integration in Peripersonal Space indexes consciousness states in sleep and disorders of consciousness. https://doi.org/10.1101/2024.10.25.619776

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