Mindfulness training impacts brain network dynamics linked to stress response in young adolescents.

Gaviria, J.; Celen, Z.; Peek, L.; Magnus, M.; Brosset, S.; Vuilleumier, P.; Van De Ville, D.; Merglen, A.; Klauser, P.; Piguet, C.

doi:10.1101/2024.10.16.616959

bioRxiv · 10.1101/2024.10.16.616959

Mindfulness training impacts brain network dynamics linked to stress response in young adolescents.

Gaviria, J.·Celen, Z.·Peek, L.·Magnus, M.·Brosset, S.·Vuilleumier, P.·Van De Ville, D.·Merglen, A.·Klauser, P.·Piguet, C.

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Abstract

Mindfulness-based interventions (MBI) may lead to lower levels of psychological distress, including depression, anxiety, and stress in adolescents. Past research has advanced the discovery of neural architecture recruited by MBI. However, the brain mechanisms through which mindfulness exerts more resilient responses to social stressors in teens remain unclear. Here, we examined how MBI modulates changes in brain network dynamics following social stress with different affective valence (i.e., neutral, negative, and positive). For this aim, we carried out a longitudinal randomized controlled trial in which non-clinical adolescents underwent MBI for 8 weeks. They completed a psychosocial stress task before and following MBI. Functional magnetic resonance imaging (fMRI) and self-reported measurements of psychological distress were collected in both measurement points (i.e., "pre" and "post" MBI). We computed co-activation patterns on fMRI data to characterize dynamic functional connectivity within whole-brain networks. The results depicted how MBI modulates transient co-activation changes in dorsal medial regions of the brain default network (DN) following the experience of stress. However, these brain changes were not specific to the affective valence of stressful stimuli. The relationship between the DN dynamics and the measurements of psychological distress was mediated by MBI. Globally, our findings support a model in which MBI causally mediate brain-behavior interactions related to psychosocial stress in adolescents.

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Gaviria, J., Celen, Z., Peek, L., Magnus, M., Brosset, S., Vuilleumier, P., Van De Ville, D., Merglen, A., Klauser, P., Piguet, C.. 2024-10-17. Mindfulness training impacts brain network dynamics linked to stress response in young adolescents.. https://doi.org/10.1101/2024.10.16.616959

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