Genomic characterization of a unique population of Leishmania tropica in a new emerging focus of cutaneous leishmaniasis in Somali region of Ethiopia

Abera, A.; Monsieurs, P.; Pareyn, M.; Beyene, D.; Tasew, G.; Aroni-Soto, A.; Belachew, M.; Geleta, D.; Adnew, B.; Gidey, B.; Tadesse, H.; G/Egziabhier, A.; Abubeker, R.; Ali, A.; Tafess, K.; Rinke de Wit, T.; van Griensven, J.; Dujardin, J.-C.; Wolday, D.; Domagalska, M. A.

doi:10.1101/2024.10.15.617758

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bioRxiv · 10.1101/2024.10.15.617758

Genomic characterization of a unique population of Leishmania tropica in a new emerging focus of cutaneous leishmaniasis in Somali region of Ethiopia

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Abstract

We sequenced Leishmania tropica genomes directly from eight human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in Somali region, Ethiopia. We found a new variant with unique genomic signatures of drug resistance. Genomic homogeneity in the sampled population demonstrates the occurrence of a L. tropica outbreak.

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Abera, A., Monsieurs, P., Pareyn, M., Beyene, D., Tasew, G., Aroni-Soto, A., Belachew, M., Geleta, D., Adnew, B., Gidey, B., Tadesse, H., G/Egziabhier, A., Abubeker, R., Ali, A., Tafess, K., Rinke de Wit, T., van Griensven, J., Dujardin, J.-C., Wolday, D., Domagalska, M. A.. 2024-10-16. Genomic characterization of a unique population of Leishmania tropica in a new emerging focus of cutaneous leishmaniasis in Somali region of Ethiopia. https://doi.org/10.1101/2024.10.15.617758

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