Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis

Gal-Er, B.; Brackenier, Y.; Bonthrone, A. F.; Casella, C.; Price, A.; Arulkumaran, S.; Chew, A. T.; Nosarti, C.; Cleri, M.; Di Cio, P.; Egloff Collado, A.; Rutherford, M.; O'Muircheartaigh, J.; Tomi-Tricot, R.; Malik, S.; Cordero-Grande, L.; Hajnal, J. V.; Counsell, S. J.

doi:10.1101/2024.10.01.616016

bioRxiv · 10.1101/2024.10.01.616016

Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis

Gal-Er, B.·Brackenier, Y.·Bonthrone, A. F.·Casella, C.·Price, A.·Arulkumaran, S.·Chew, A. T.·Nosarti, C.·Cleri, M.·Di Cio, P.·Egloff Collado, A.·Rutherford, M.·O'Muircheartaigh, J.·Tomi-Tricot, R.·Malik, S.·Cordero-Grande, L.·Hajnal, J. V.·Counsell, S. J.

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Abstract

PurposeTo validate a retrospective motion correction technique, Distributed and Incoherent Sample Orders for Reconstruction Deblurring using Encoding Redundancy (DISORDER), for pediatric brain morphometry. MethodsTwo T1-weighted MPRAGE 3D datasets were acquired at 3T in thirty-seven children, median age 7.75 years; one with conventional linear phase encoding and one using DISORDER. MPRAGE images were scored as motion-free or motion-corrupt. Cortical morphometry and regional brain volumes were measured with FreeSurfer, subcortical grey matter (GM) with FSL-FIRST, and hippocampal volumes with HippUnfold. Intraclass correlation coefficient (ICC) was used to determine agreement between the 2 MPRAGE acquisitions. Mann-Whitney U was used to test the difference between measures obtained using DISORDER and (i) motion-free and (ii) motion-corrupt conventional MPRAGE data. ResultsICC measures were good/excellent for most subcortical GM (motion-free, 0.75-0.96; motion-corrupt, 0.62-0.98) and regional brain volumes (motion-free 0.47-0.99; motion-corrupt, 0.54-0.99) between conventional MPRAGE and DISORDER data, except for the amygdala and nucleus accumbens (motion-free, 0.38-0.65; motion- corrupt, 0.1-0.42). However, these values were less consistent for motion-corrupt conventional MPRAGE data for hippocampal volumes (motion-free 0.65-0.99; motion-corrupt, 0.11-0.91) and cortical measures (motion-free 0.76-0.98; motion- corrupt, 0.09-0.74). Mann-Whitney U showed percentage differences in measures obtained with motion-corrupt conventional MPRAGE compared to DISORDER data were significantly greater than in those obtained using motion-free conventional MPRAGE data in 22/58 structures. ConclusionIn the absence of motion, morphometric measures obtained using DISORDER are largely consistent with those from conventional MPRAGE data, whereas improved reliability is obtained by DISORDER for motion-degraded scans. This study validates DISORDER for brain morphometric studies in children.

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Gal-Er, B., Brackenier, Y., Bonthrone, A. F., Casella, C., Price, A., Arulkumaran, S., Chew, A. T., Nosarti, C., Cleri, M., Di Cio, P., Egloff Collado, A., Rutherford, M., O'Muircheartaigh, J., Tomi-Tricot, R., Malik, S., Cordero-Grande, L., Hajnal, J. V., Counsell, S. J.. 2024-10-02. Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis. https://doi.org/10.1101/2024.10.01.616016

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