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bioRxiv · 10.1101/2024.09.20.614058

Mitochondrial Transplantation: Adaptive Bio-enhancement

Lu, X.·Jiang, Y.
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Abstract

Mitochondria, often referred to the powerhouse of the cell, are essential for cellular energy production, and their dysfunction can profoundly affect various organs. Transplantation of healthy mitochondria can restore the bioenergetics in diseased cells and address multiple conditions, but more potentials of this approach remain unclear. In this study, I demonstrated that the source of transplanted mitochondria is not limited by species, as exhibit no significant responses to mitochondria derived from different germlines. Moreover, I identified that metabolic compatibility between the recipient and exogenous mitochondria as a crucial factor in mitochondrial transplantation, which confers unique metabolic properties to recipient cells, enabling them to combat diseases. Additionally, my findings indicated competitive interactions among mitochondria with varying functions, with more bioenergetic-active mitochondria yielded superior therapeutic benefits. Notably, no upper limit for the bio-enhancement provided by exogenous mitochondria has been identified. Based on these insights, I proposes a novel therapeutic approach--adaptive bio-enhancement through mitochondrial transplantation.

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Lu, X., Jiang, Y.. 2024-09-23. Mitochondrial Transplantation: Adaptive Bio-enhancement. https://doi.org/10.1101/2024.09.20.614058

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