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bioRxiv · 10.1101/2024.09.06.611514

Semaglutide Administration in Healthy Mice Alters Behaviour Related to Stress and Motivation

Moreno, A.·Ansarifar, S.·Mosqueira, A.·Nabavi, S.
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Abstract

Semaglutide, a GLP-1 receptor agonist, is widely studied in metabolic disorders, yet its effects in healthy subjects remain unclear. Here, we show that daily administration of semaglutide (0.1 mg/kg) in healthy mice alters behaviour in various tests related to stress and reward pursuit. Additionally, acute administration of semaglutide changes the oscillatory activity in the nucleus accumbens in the delta, theta and alpha bands. These findings reveal that semaglutide impacts both behaviour and neural dynamics in non-diseased brains, offering a baseline for interpreting its broader therapeutic potential.

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Moreno, A., Ansarifar, S., Mosqueira, A., Nabavi, S.. 2024-09-10. Semaglutide Administration in Healthy Mice Alters Behaviour Related to Stress and Motivation. https://doi.org/10.1101/2024.09.06.611514

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