Evolution of lateralized gustation in nematodes

Mackie, M.; Le, V. V.; Carstensen, H. R.; Kushnir, N. R.; Castro, D. L.; Dimov, I. M.; Quach, K. T.; Cook, S. J.; Hobert, O.; Chalasani, S. H.; Hong, R. L.

doi:10.1101/2024.08.31.610597

bioRxiv · 10.1101/2024.08.31.610597

Evolution of lateralized gustation in nematodes

Mackie, M.·Le, V. V.·Carstensen, H. R.·Kushnir, N. R.·Castro, D. L.·Dimov, I. M.·Quach, K. T.·Cook, S. J.·Hobert, O.·Chalasani, S. H.·Hong, R. L.

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Abstract

Animals with small nervous systems have a limited number of sensory neurons that must encode information from a changing environment. This problem is particularly exacerbated in nematodes that populate a wide variety of distinct ecological niches but only have a few sensory neurons available to encode multiple modalities. How does sensory diversity prevail within this constraint in neuron number? To identify the genetic basis for patterning different nervous systems, we demonstrate that sensory neurons in Pristionchus pacificus respond to various salt sensory cues in a manner that is partially distinct from that of the distantly related nematode Caenorhabditis elegans. By visualizing neuronal activity patterns, we show that contrary to previous expectations based on its genome sequence, the salt responses of P. pacificus are encoded in a left/right asymmetric manner in the bilateral ASE neuron pair. Our study illustrates patterns of evolutionary stability and change in the gustatory system of nematodes. Animals with small nervous systems have evolved left and right asymmetry in their neurons to process various salts at different concentrations.

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Mackie, M., Le, V. V., Carstensen, H. R., Kushnir, N. R., Castro, D. L., Dimov, I. M., Quach, K. T., Cook, S. J., Hobert, O., Chalasani, S. H., Hong, R. L.. 2024-09-02. Evolution of lateralized gustation in nematodes. https://doi.org/10.1101/2024.08.31.610597

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