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bioRxiv · 10.1101/2024.08.30.610468

Immunological memory in a teleost fish: common carp IgM+ B cells differentiate into memory and plasma cells

Abstract

From ancient cold-blooded fishes to mammals, all vertebrates are protected by adaptive immunity, and retain immunological memory. Although immunologists can demonstrate these phenomena in all fish, the responding cells remain elusive for lack of defining markers and tools to study them. Fundamentally, we posited that it is longevity that defines a memory cell like how antibody production defines a plasma cell. We infected the common carp with Sphaerospora molnari, a cnidarian parasite which causes seasonal outbreaks to which no vaccine is available. B cells proliferated and expressed gene signatures of differentiation. Despite a half-year gap between EdU labeling and sampling, B cells retained the thymidine analogue, suggesting that these are at least six-month-old resting memory cells stemming from proliferating precursors. Additionally, we identified a lymphoid organ-resident population expressing exceptional levels of IgM as plasma cells. Thus, teleost fish produce the lymphocytes key to vaccination success and long-term disease protection, and immunological memory is universal and universally demonstrable.

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Chan, J. T. H., Picard-Sanchez, A., Dedic, N., Majstorovic, J., Rebl, A., Holzer, A. S., Korytar, T.. 2024-08-30. Immunological memory in a teleost fish: common carp IgM+ B cells differentiate into memory and plasma cells. https://doi.org/10.1101/2024.08.30.610468

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