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bioRxiv · 10.1101/2024.08.20.608830

ANGIOTENSIN CONVERTING ENZYME HUB CAPACITY - A SIMPLE MODEL OF RELATING PEPTIDE FLUX AND RENIN INFLUENCE

Westwood, B. M.·Chappell, M. C.
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Abstract

Utilizing data from the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial, this hub model was developed to limit seventeen Renin-Angiotensin-Aldosterone System (RAAS) components as three entrance and four exits, to facilitate the calculation of a model as one egress unknown, the angiotensin type 1 (AT1) receptor. Following previous evidence relating renin levels to mortality, this study found controls were more like sepsis patients with levels < renin quartile 1 (Q1) for calculated AT1, while more like sepsis patients with renin levels > quartile 3 (Q4) for measured aldosterone levels. Additionally differential discrete correlate summation (DCS) analysis indicates AT1, aldosterone and renin as major hub nodes in this independent DCS model of metabolic data inputs.

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Westwood, B. M., Chappell, M. C.. 2024-08-21. ANGIOTENSIN CONVERTING ENZYME HUB CAPACITY - A SIMPLE MODEL OF RELATING PEPTIDE FLUX AND RENIN INFLUENCE. https://doi.org/10.1101/2024.08.20.608830

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