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bioRxiv · 10.1101/2024.08.19.607534

Neither fifty percent slow-wave sleep suppression nor fifty percent rapid eye movement sleep suppression does impair memory consolidation

Ukraintseva, Y. V.·Saltykov, K. A.·Tkachenko, O. N.
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Abstract

Establishing well-defined relationships between sleep features and memory consolidation is essential in comprehending the pathophysiology of cognitive decline commonly seen in patients with insomnia, depression, and other sleep-disrupting conditions. Twenty-eight volunteers participated in two experimental sessions: a session with selective SWS suppression during one night and a session with undisturbed night sleep (as a control condition). Fifteen of them also participated in a third session with REM suppression. Suppression was achieved by presenting an acoustic tone. In the evening and the morning, the participants completed procedural and declarative memory tasks and the Psychomotor vigilance task (PVT). Heart rate variability analysis and salivary cortisol were used to control possible stress reactions on sleep interference. SWS and REM suppression led to more than 50 percent reduction in amount of these stages. Neither vigilance nor memory consolidation was impaired after SWS or REM suppression. Unexpectedly, a beneficial effect of selective SWS suppression on PVT performance was found. Similarly, after a night with SWS suppression, the overnight improvement in procedural skills was higher than after a night with REM suppression and after a night with undisturbed sleep. Our data brings into question the extent to which SWS and REM are truly necessary for effective memory consolidation to proceed. Moreover, SWS suppression may even improve the performance of some tasks, possibly by reducing sleep inertia associated with undisturbed sleep. HighlightsOur data brings into question the extent to which SWS and REM are truly necessary for effective memory consolidation to proceed. Provided that sleep disturbances do not cause stress, half the usual amount of SWS or REM is sufficient for procedural and declarative memory consolidation. Moreover, SWS suppression may even improve the performance of psychomotor vigilance task and finger sequence tapping task, possibly by reducing sleep inertia associated with undisturbed night sleep.

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Ukraintseva, Y. V., Saltykov, K. A., Tkachenko, O. N.. 2024-08-21. Neither fifty percent slow-wave sleep suppression nor fifty percent rapid eye movement sleep suppression does impair memory consolidation. https://doi.org/10.1101/2024.08.19.607534

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