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bioRxiv · 10.1101/2024.08.18.608454

Cell type and locus-specific epigenetic editing of memory expression

Coda, D. M.·WATT, L.·glauser, l.·Batiuk, M.·Burns, A.·Stahl, C.·Graeff, J.
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Abstract

Epigenetic modifications parallel multiple memory processes, but evidence that the epigenetic makeup of a single site can guide learnt behaviors has so far been lacking. Here, we developed CRISPR-based epigenetic editing tools to address this question in a cell type-specific, locus-restricted and temporally controllable manner in the adult mouse brain. Focusing on learning-induced neuronal populations, we provide a proof-of-principle that site-specific epigenetic dynamics are causally implicated in memory expression.

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Coda, D. M., WATT, L., glauser, l., Batiuk, M., Burns, A., Stahl, C., Graeff, J.. 2024-08-18. Cell type and locus-specific epigenetic editing of memory expression. https://doi.org/10.1101/2024.08.18.608454

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