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bioRxiv · 10.1101/2024.08.09.607292

Characterization of Postsynaptic Glutamate Transporter Functionality in the Zebrafish Retinal First Synapse Across Different Wavelengths

Abstract

In the zebrafish retina, incident light undergoes wavelength-dependent processing encompassing mechanisms such as color opponency, contrast enhancement, and motion detection prior to neural transmission to the brain proper. In darkness, photoreceptors continuously release glutamate into the synaptic cleft, a process that diminishes in response to increased light intensity, thereby conveying visual signals to ON and OFF bipolar cells. Specifically, in zebrafish, the ON pathway signal transduction is mediated by metabotropic glutamate receptor 6b (mGluR6b) and Excitatory Amino Acid Transporters (EAATs). Here we demonstrate that knockout of eaat5b and eaat7 disrupts electroretinogram responses to short and long-wavelength stimuli while preserving middlewavelength responses, suggesting wavelength-specific roles. We found differential expression of EAAT5b and EAAT7 in the outer plexiform layer, particularly in the strike zone, crucial for prey capture, supporting task specific involvement of these signaling pathways. In order to investigate this, we developed a virtual hunting assay using UV light stimuli. Such a behavioral assay targeting short and long wavelengths indicate that EAAT5b and EAAT7 influence UV-dependent prey detection and motion sensing differently. Our findings highlight the importance of EAAT5b and EAAT7 in modulating light integration dynamics in the zebrafish retina.

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BibTeXRIS

Garbelli, M., Niklaus, S., Neuhauss, S. C.. 2024-08-09. Characterization of Postsynaptic Glutamate Transporter Functionality in the Zebrafish Retinal First Synapse Across Different Wavelengths. https://doi.org/10.1101/2024.08.09.607292

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