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bioRxiv · 10.1101/2024.08.05.606613

Zinc and Metformin Co-Functionalized Polyetheretherketone: A Novel Dental Implant Material Tailored for the Elderly

Liu, Z.·Zhao, E.·Huang, H.·Wu, Y.·He, Y.·Bai, S.·Wang, S.·Fan, S.·Cao, S.·Tang, B.·Wang, Y.
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Abstract

This study focuses on addressing the challenges of dental implants in the geriatric population by enhancing the bioactivity of polyetheretherketone (PEEK) through surface modification. PEEK, with its elastic modulus close to alveolar bone, mitigates stress shielding but faces limitations in osseointegration due to low bioactivity. We introduced zinc (Zn) and metformin (MF) onto PEEK surfaces via a dopamine-assisted physical adhesion method, creating a functionalized derivative called ZnMF@PEEK. This combination targets diminished osteogenic potential, persistent inflammation, and cell senescence, which are common issues in elderly patients. Comprehensive physicochemical characterizations confirmed the successful preparation of ZnMF@PEEK, and in vitro and in vivo experiments systematically evaluated its biocompatibility and bioactivity. The results indicate that ZnMF@PEEK holds promise as a dental implant material tailored to the specific needs of the elderly, addressing multifaceted challenges in osseointegration.

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Liu, Z., Zhao, E., Huang, H., Wu, Y., He, Y., Bai, S., Wang, S., Fan, S., Cao, S., Tang, B., Wang, Y.. 2024-08-07. Zinc and Metformin Co-Functionalized Polyetheretherketone: A Novel Dental Implant Material Tailored for the Elderly. https://doi.org/10.1101/2024.08.05.606613

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