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bioRxiv · 10.1101/2024.07.31.606105

PDS5s control the Arabidopsis 3D genome by suppressing the formation of TAD-like domains

Goebel, A. M.·Zhou, S.·Wang, Z.·Tzourtzou, S.·Himmelbach, A.·Zheng, S.·Pradillo, M.·Liu, C.·JIANG, H.
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Abstract

One key structural element in the three-dimensional (3D) chromatin organization is the Topologically Associating Domain (TAD), which facilitates the formation of distinct chromatin compartments and fosters specific chromatin interactions. Similar chromatin compartments, known as TAD-like domains, have been identified in many plant species. However, the model plant Arabidopsis thaliana has been an exception. In this study, we address this long-standing issue by presenting evidence that Arabidopsis PDS5 proteins play a crucial role in preventing the formation of TAD-like domains.

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Goebel, A. M., Zhou, S., Wang, Z., Tzourtzou, S., Himmelbach, A., Zheng, S., Pradillo, M., Liu, C., JIANG, H.. 2024-08-01. PDS5s control the Arabidopsis 3D genome by suppressing the formation of TAD-like domains. https://doi.org/10.1101/2024.07.31.606105

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