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bioRxiv · 10.1101/2024.07.30.605411

Anisotropic Articular Cartilage Biofabrication based on Decellularized Extracellular Matrix

Abstract

Tissue-engineered grafts that mimic articular cartilage show promise for treating cartilage injuries. However, engineering cartilage cell-based therapies to match zonal architecture and biochemical composition remains challenging. Decellularized articular cartilage extracellular matrix (dECM) has gained attention for its chondro-inductive properties, yet dECM-based bioinks have limitations in mechanical stability and printability. This study proposes a rapid light-based bioprinting method using a tyrosine-based crosslinking mechanism, which does not require chemical modifications of dECM and thereby preserves its structure and bioactivity. Combining this resin with Filamented Light (FLight) biofabrication enables the creation of cellular, porous, and anisotropic dECM scaffolds composed of aligned microfilaments. Specifically, we investigate the effects of various biopolymer compositions (i.e., hyaluronic acid, collagen I, and dECM) and inner architecture (i.e., bulk light vs FLight) on immune response and cell morphology, and we investigate their influence on nascent ECM production and long-term tissue maturation. Our findings highlight the importance of FLight scaffolds in directing collagen deposition resembling articular cartilage structure and promoting construct maturation, and they emphasize the superiority of biological-rich dECM over single-component materials for engineering articular cartilage, thereby offering new avenues for the development of effective cartilage tissue engineering strategies.

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BibTeXRIS

Puiggali-Jou, A., Hui, I., Baldi, L., Frischknecht, R., Asadikorayem, M., Janiak, J., Chansoria, P., McCabe, M. C., Stoddart, M. J., Hansen, K., Christman, K. L., Zenobi, M.. 2024-07-30. Anisotropic Articular Cartilage Biofabrication based on Decellularized Extracellular Matrix. https://doi.org/10.1101/2024.07.30.605411

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