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bioRxiv · 10.1101/2024.07.18.603826

Human reproduction comes at the expense of faster aging and a shorter life

Hukkanen, M.·Kankaanpaa, A.·Heikkinen, A.·Kaprio, J.·Cristofari, R.·Ollikainen, M.
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Abstract

Evolutionary theories suggest a trade-off between resources allocated to reproduction and those allocated to self-maintenance, and predict that higher reproductive output entails a shorter lifespan. This study investigates the impact of childbearing on aging and lifespan using data from contemporary Finnish twin women. We model the association between reproductive trajectories and survival in 17,080 women, and assess biological aging in a subset of participants (N=1,117) using the PCGrimAge clock, an algorithm trained to predict biological aging and mortality risk from DNA methylation. Our findings suggest that early childbearing, numerous pregnancies or nulliparity all contribute to accelerated aging and increased mortality risk. These results provide strong evidence for the existence of a trade-off between reproduction, aging and lifespan in modern humans, and provide novel insights into the genetic and lifestyle determinants of healthspan.

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Hukkanen, M., Kankaanpaa, A., Heikkinen, A., Kaprio, J., Cristofari, R., Ollikainen, M.. 2024-07-19. Human reproduction comes at the expense of faster aging and a shorter life. https://doi.org/10.1101/2024.07.18.603826

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