Antiparasitic effect of peptoids against Cryptosporidium parvum

Lamont, B.; Russell, B. M.; Suwanarusk, R.; Nielsen, J. E.; Sorensen, K.; Yung, D.; Barron, A.; Pletzer, D.; Muhsin-Sharafaldine, M.-R.

doi:10.1101/2024.07.16.603782

bioRxiv · 10.1101/2024.07.16.603782

Antiparasitic effect of peptoids against Cryptosporidium parvum

Lamont, B.·Russell, B. M.·Suwanarusk, R.·Nielsen, J. E.·Sorensen, K.·Yung, D.·Barron, A.·Pletzer, D.·Muhsin-Sharafaldine, M.-R.

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Abstract

Cryptosporidiosis, caused by Cryptosporidium parvum, poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of against C. parvum. Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity without harming host cells. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.

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Lamont, B., Russell, B. M., Suwanarusk, R., Nielsen, J. E., Sorensen, K., Yung, D., Barron, A., Pletzer, D., Muhsin-Sharafaldine, M.-R.. 2024-07-19. Antiparasitic effect of peptoids against Cryptosporidium parvum. https://doi.org/10.1101/2024.07.16.603782

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