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bioRxiv · 10.1101/2024.07.10.602866

Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

Abstract

Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during exercise is a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role of gut microbes in intestinal homeostasis. Here, we characterize and compare the effects of moderate and vigorous exercise training on intestinal epithelial damage, stress response, inflammatory response, and gut microbiota alterations in mice and investigate the mechanisms underlying exercise-induced intestinal injury. Exercise training for six weeks caused heat stress in the intestine, resulting in the disruption of the intestinal epithelial barrier and local inflammation. This was characterized by increased colonic HSP-70 and HSF-1 protein expression, increased epithelial permeability, decreased colonic expression of tight junction proteins ZO-1 and occludin and intestinal morphological changes. Daily moderate exercise training caused hereby more severe injury than vigorous training on alternating days. Furthermore, exercise training altered the gut microbiota profile. The abundance of Lactobacillaceae was reduced, potentially contributing to the deteriorated intestinal status, while the abundance of short-chain fatty acid-producing Lachnospiraceae was increased, especially following vigorous training. This increase in short-chain fatty acid-producing bacteria following vigorous training possibly counteracted the impairment of the intestinal barrier function. In summary, exercise disrupts the intestinal barrier function, with vigorous exercise training with intermittent rest days being less damaging than daily moderate exercise training.

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Lian, P., Kovynev, A., Wang, L., Pronk, A. C. M., Verhoeven, A., Giera, M., Thijssen, S., Martinez Tellez, B., Kooijman, S., Rensen, P. C., Timmerman, H., Wichers, H. J., Henricks, P. A. J., Folkerts, G., Schonke, M., Braber, S.. 2024-07-14. Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice. https://doi.org/10.1101/2024.07.10.602866

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